The 12-transmembrane helix transporters

被引：136
作者：
Henderson, Peter J. F. [1 ]
机构：
[1] Univ Leeds, Dept Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0955-0674(93)90144-F
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
From the hydropathic profiles of their amino acid sequences many transport proteins are conceived to comprise 12-transmembrane alpha-helices. In only a few examples, however, is there genetical and/or biochemical evidence to support the 12-helix structure or illuminate the molecular mechanism of the transport process. A number of these transport proteins occur in evolutionarily related families, and sometimes superfamilies, indicating divergent evolution of the 12-helix structure. Other individual members or families of transport proteins are sufficiently different in amino acid sequence for their evolution to have taken place by convergence from independent ancestral origins.
引用
收藏
页码：708 / 721
页数：14
相关论文
共 78 条
[1]   TOPOLOGY ANALYSIS OF THE SECY PROTEIN, AN INTEGRAL MEMBRANE-PROTEIN INVOLVED IN PROTEIN EXPORT IN ESCHERICHIA-COLI [J].
AKIYAMA, Y ;
ITO, K .
EMBO JOURNAL, 1987, 6 (11) :3465-3470
[2]  
ALLARD JD, 1992, J BIOL CHEM, V267, P17809
[3]   SV2, A BRAIN SYNAPTIC VESICLE PROTEIN HOMOLOGOUS TO BACTERIAL TRANSPORTERS [J].
BAJJALIEH, SM ;
PETERSON, K ;
SHINGHAL, R ;
SCHELLER, RH .
SCIENCE, 1992, 257 (5074) :1271-1273
[4]  
BALDWIN SA, 1992, NEW COMPREHENSIVE BI, V21, P169
[5]   CLONING AND SEQUENCE-ANALYSIS OF AN ESCHERICHIA-COLI GENE CONFERRING BICYCLOMYCIN RESISTANCE [J].
BENTLEY, J ;
HYATT, LS ;
AINLEY, K ;
PARISH, JH ;
HERBERT, RB ;
WHITE, GR .
GENE, 1993, 127 (01) :117-120
[6]   FUNCTIONAL COMPLEMENTATION OF INTERNAL DELETION MUTANTS IN THE LACTOSE PERMEASE OF ESCHERICHIA-COLI [J].
BIBI, E ;
KABACK, HR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1524-1528
[7]   THE N-TERMINAL 22 AMINO-ACID-RESIDUES IN THE LACTOSE PERMEASE OF ESCHERICHIA-COLI ARE NOT OBLIGATORY FOR MEMBRANE INSERTION OR TRANSPORT ACTIVITY [J].
BIBI, E ;
STEARNS, SM ;
KABACK, HR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3180-3184
[8]  
BISSON IF, 1993, CRC CRIT RE IN PRESS
[9]   CHARACTERIZATION OF A CHROMOSOMALLY ENCODED, NON-PTS METABOLIC PATHWAY FOR SUCROSE UTILIZATION IN ESCHERICHIA-COLI EC3132 [J].
BOCKMANN, J ;
HEUEL, H ;
LENGELER, JW .
MOLECULAR AND GENERAL GENETICS, 1992, 235 (01) :22-32
[10]   FUNCTIONAL EXPRESSION OF A PLANT PLASMA-MEMBRANE TRANSPORTER IN XENOPUS OOCYTES [J].
BOORER, KJ ;
FORDE, BG ;
LEIGH, RA ;
MILLER, AJ .
FEBS LETTERS, 1992, 302 (02) :166-168
12345678