Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report

被引：5

作者：

Kwon, Yong Shik ^{[1
]}

Jung, Hye In ^{[1
]}

Kim, Hyun Jung ^{[1
]}

Lee, Jin Wook ^{[1
]}

Choi, Won-Il ^{[1
]}

Kim, Jin Young ^{[2
]}

Rho, Byung Hak ^{[2
]}

Lee, Hye Won ^{[3
]}

Kwon, Kun Young ^{[3
]}

机构：

[1] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Internal Med, 56 Dalseong Ro, Daegu 700712, South Korea

[2] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Radiol, Daegu, South Korea

[3] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Pathol, Daegu, South Korea

来源：

TUBERCULOSIS AND RESPIRATORY DISEASES | 2013年 / 75卷 / 03期

关键词：

Sarcoidosis; Lymphatic Diseases; Neck; Immunohistochemistry;

D O I：

10.4046/trd.2013.75.3.116

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-a in the granuloma. However, transforming growth factor-1 beta was not expressed, although interleukin-beta was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma.

引用

页码：116 / 119

页数：4

共 12 条

[1]

Baughman R.P., Lower E.E., Du Bois R.M., Sarcoidosis, Lancet, 361, pp. 1111-1118, (2003)

[2]

Iannuzzi M.C., Rybicki B.A., Teirstein A.S., Sarcoidosis, N Engl J Med, 357, pp. 2153-2165, (2007)

[3]

Giuffrida T.J., Kerdel F.A., Sarcoidosis, Dermatol Clin, 20, pp. 435-447, (2002)

[4]

Handa R., Aggarwal P., Wali J.P., Wig N., Dinda A.K., Biswas A., Sarcoidosis presenting with peripheral lymphadenopathy, Sarcoidosis Vasc Diffuse Lung Dis, 15, (1998)

[5]

Saltini C., Crystal R.G., Pulmonary sarcoidosis: Pathogenesis, staging and therapy, Int Arch Allergy Appl Immunol, 76, SUPPL. 1, pp. 92-100, (1985)

[6]

Newman L.S., Rose C.S., Bresnitz E.A., Rossman M.D., Barnard J., Frederick M., Et al., A case control etiologic study of sarcoidosis: Environmental and occupational risk factors, Am J Respir Crit Care Med, 170, pp. 1324-1330, (2004)

[7]

Knopf A., Lahmer T., Chaker A., Stark T., Hofauer B., Pickhard A., Et al., Head and neck sarcoidosis, from wait and see to tumor necrosis factor alpha therapy: A pilot study, Head Neck, 35, pp. 715-719, (2013)

[8]

Daien C.I., Monnier A., Claudepierre P., Constantin A., Eschard J.P., Houvenagel E., Et al., Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 Cases, Rheumatology, 48, pp. 883-886, (2009)

[9]

Fehrenbach H., Zissel G., Goldmann T., Tschernig T., Vollmer E., Pabst R., Et al., Alveolar macrophages are the main source for tumour necrosis factor-alpha in patients with sarcoidosis, Eur Respir J, 21, pp. 421-428, (2003)

[10]

Limper A.H., Colby T.V., Sanders M.S., Asakura S., Roche P.C., DeRemee R.A., Immunohistochemical localization of transforming growth factor-beta 1 in the nonnecrotizing granulomas of pulmonary sarcoidosis, Am J Respir Crit Care Med, 149, pp. 197-204, (1994)

← 1 2 →