Neurosarcoidosis following Immune Checkpoint Inhibition

被引：27

作者：

Dunn-Pirio, Anastasie M. ^{[1
]}

Shah, Suma ^{[1
]}

Eckstein, Christopher ^{[1
]}

机构：

[1] Duke Univ, Dept Neurol, Durham, NC USA

来源：

CASE REPORTS IN ONCOLOGY | 2018年 / 11卷 / 02期

关键词：

Immunotherapy; Immune-related adverse event; Immune checkpoint inhibitor; Neurosarcoidosis; Nivolumab; Ipilimumab;

D O I：

10.1159/000491599

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, immune checkpoint inhibitors have revolutionized cancer care by enhancing antitumor immunity. However, by virtue of stimulating the immune system, they can lead to immune-related adverse events (irAEs). Neurologic irAEs are uncommon but are becoming increasingly recognized and can be quite serious or even fatal. Furthermore, central nervous system (CNS) manifestations may be difficult to distinguish from CNS metastases, posing management challenges. Here, we describe a patient who developed exacerbation of sarcoidosis leading to CNS involvement following dual checkpoint blockade with nivolumab and ipilimumab for metastatic melanoma and review the relevant literature. (C) 2018 The Author(s) Published by S. Karger AG, Basel

引用

页码：521 / 526

页数：6

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