IMMUNOGENETIC STUDY OF THYROID-HORMONE AUTOANTIBODIES IN A FAMILY

被引：2

作者：

NAKAMURA, S

SUGIMOTO, M

KOSAKA, J

KOMAKI, T

KAMURA, H

MIYAZAKI, T

MATSUMOTO, H

SAKATA, S

机构：

[1] HASHIMA MUNICIPAL HOSP,DEPT INTERNAL MED,GIFU 50162,JAPAN

[2] NAGOYA SECOND RED CROSS HOSP,HISTOCOMPATABIL LAB,NAGOYA,AICHI 466,JAPAN

[3] OSAKA MED COLL,DEPT LEGAL MED,TAKATSUKI,OSAKA 569,JAPAN

[4] GIFU UNIV,SCH MED,DEPT INTERNAL MED 3,GIFU 500,JAPAN

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1991年 / 14卷 / 02期

关键词：

THYROID HORMONE AUTOANTIBODIES; HLA ANTIGENS; IMMUNOGLOBULIN ALLOTYPE;

D O I：

10.1007/BF03350284

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Haplotypes of the human major histocompatibility complex (HLA) and immunoglobulin G heavy chain allotype (Gm) were determined in nine members of a family in which three sisters had thyroid hormone autoantibodies (THAA) in serum. Among three sisters with THAA, two of them were hypothyroid and treated with synthetic thyroid hormones (patients nos. 1 and 2). The other remaining sister (patient no. 3) was euthyroid. Light chain allotype (Km) in them was also examined. Three patients had the same two Gm haplotypes. Km (1) allotype was negative in these three patients. HLA haplotypes of patient no. 1 were the same as those of patient no. 2. However, HLA haplotypes of patient no. 3 were completely different from those of patients nos. 1 and 2. The same combination of Gm haplotypes and the absence of Km (1) allotype were not observed in the remaining members without THAA. These results suggest that genes linked to Gm and Km allotypes are associated with the production of THAA at least in our patients.

引用

页码：131 / 134

页数：4