INCREASED EXPRESSION OF THE EMBRYONIC FORM OF A DEVELOPMENTALLY REGULATED MESSENGER-RNA IN ALZHEIMERS-DISEASE

被引：60
作者：
GEDDES, JW
WONG, J
CHOI, BH
KIM, RC
COTMAN, CW
MILLER, FD
机构：
[1] UNIV CALIF IRVINE, DEPT PATHOL, IRVINE, CA 92717 USA
[2] UNIV CALIF IRVINE, DEPT PSYCHOBIOL, IRVINE, CA 92717 USA
[3] UNIV ALBERTA, DEPT ANAT & CELL BIOL, EDMONTON T6G 2E1, ALBERTA, CANADA
来源：
NEUROSCIENCE LETTERS | 1990年 / 109卷 / 1-2期
基金：
英国医学研究理事会;
关键词：
Alzheimer's disease; Development; In situ hybridization; Messenger RNA; Sprouting; Tubulin;
D O I：
10.1016/0304-3940(90)90537-J
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
There is increasing evidence that an aberrant sprouting response may contribute to some of the neuronal alterations observed in Alzheimer's disease (AD). In this study, we demonstrate that in the rat CNS, sprouting results in the reinduction of the embryonic form of the mRNA for α-tubulin. The fetal form of α-tubulin mRNA was also elevated in the hippocampus obtained from five AD patients, as compared to five elderly controls. These results suggest that the reexpression of embryonic forms of cytoskeletal proteins, in association with an aberrant sprouting response, may contribute to the neuropathological alterations in AD. © 1990.
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页码：54 / 61
页数：8
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