CDNA CLONING OF MURINE NRF2 GENE, CODING FOR A P45 NF-E2 RELATED TRANSCRIPTION FACTOR

被引：58
作者：
CHUI, DHK [1 ]
TANG, WZ [1 ]
ORKIN, SH [1 ]
机构：
[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,HOWARD HUGHES MED INST,DEPT PEDIAT,DIV HEMATOL,BOSTON,MA 02115
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 01期
关键词：
D O I：
10.1006/bbrc.1995.1467
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A lambda gt11 cDNA library was constructed from poly-A rich RNA prepared from circulating murine yolk sac derived nucleated erythroblasts, on day 9 of gestation. In addition to the embryonic globin genes, this library was found to contain clones for the hematopoietic specific p45 NF-E2, as web as p18 NF-E2 and p45 NF-E2 related factor 1 (Nrf 1) genes. Using a degenerate oligonucleotide 17mer probe coding for a part of the highly conserved DNA binding domain for p45 NF-E2, we have isolated murine Nrf 2, a second murine homologue related to p45 NF-E2. The murine Nrf 2 gene is expressed not only in erythroid cells, but also in the 3T3 murine fibroblast cell line. (C) 1995 Academic Press, Inc.
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页码：40 / 46
页数：7
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