Changes of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits in rat cerebral cortex during aging

被引：29

作者：

Nicoletti, VG

Tendi, EA

Lalicata, C

Reale, S

Costa, A

Villa, RF

Ragusa, N

Stella, AMG

机构：

[1] UNIV CATANIA,FAC MED,INST BIOCHEM,I-95125 CATANIA,ITALY

[2] UNIV PAVIA,FAC SCI,INST PHARMACOL,I-27100 PAVIA,ITALY

来源：

NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 12期

关键词：

cytochrome c oxidase; FoF1 ATP synthase; aging;

D O I：

10.1007/BF00970595

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The contents of subunits I, II/III, and IV of cytochrome c oxidase and of subunits alpha, beta and gamma of FoF1 ATP synthase in inner mitochondrial membrane proteins purified from cerebral cortex of rat at 2, 6, 12, 18, 24, and 26 months of age were analyzed by western blot. Age-related changes in the content of subunits, either of mitochondrial or nuclear origin, were observed. All the cytochrome c oxidase (COX) subunits examined showed an age-related increase from 2-month-old rats up to 24 months with a decrease at the oldest age (26 months). The same pattern of age-dependent changes was observed for gamma ATP synthase, while the or and beta subunits increased progressively up to 26 months.

引用

页码：1465 / 1470

页数：6