HEMODYNAMIC VARIABILITY AND CIRCADIAN-RHYTHM IN RATS WITH HEART-FAILURE - ROLE OF LOCOMOTOR-ACTIVITY

被引：30

作者：

TEERLINK, JR ^{[1
]}

CLOZEL, JP ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD, DIV PHARMA, PRECLIN RES, CH-4002 BASEL, SWITZERLAND

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 06期

关键词：

HEART RATE VARIABILITY; BLOOD PRESSURE VARIABILITY; SPECTRAL ANALYSIS; MYOCARDIAL INFARCTION;

D O I：

10.1152/ajpheart.1993.264.6.H2111

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Heart rate variability is known to be decreased by heart failure; however, the influences of concomitant diseases, changes in activity level, evolution through time, and abnormalities in the circadian rhythm are unknown. This study evaluated the influence of these factors by assessing hemodynamic variability in rats with heart failure (n = 8) and sham-operated controls (n = 8) through telemetric monitoring of heart rate, blood pressure, and locomotor activity for 8 wk. Hemodynamic variability was assessed by the standard deviation as well as hourly standard deviations and coefficients of variation of these variables over 48 h at 2, 4, and 8 wk after myocardial infarction. The circadian rhythm was investigated through power spectral analysis. Heart failure was associated with marked decreases in heart rate and mean arterial pressure variability and circadian rhythm without any differences in activity and no change through time. Heart failure in rats due to myocardial infarction in the absence of any confounding diseases is associated with marked abnormalities in hemodynamic variability and circadian rhythm independent of locomotor activity.

引用

页码：H2111 / H2118

页数：8

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