ANTIPYRINE ELIMINATION IN CRITICALLY ILL PATIENTS

被引：3
作者：
MIRVIS, L
BUCHANAN, N
EYBERG, C
机构：
[1] BARAGWANATH HOSP,METAB UNIT,JOHANNESBURG 2013,SOUTH AFRICA
[2] BARAGWANATH HOSP,INTENS CARE UNIT,JOHANNESBURG 2013,SOUTH AFRICA
[3] BARAGWANATH HOSP,METAB & NUTR RES UNIT,JOHANNESBURG 2013,SOUTH AFRICA
来源：
INTENSIVE CARE MEDICINE | 1979年 / 5卷 / 02期
关键词：
Antipyrine kinetics; critically ill patients; hepatic microsomal oxidation;
D O I：
10.1007/BF01686049
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Antipyrine kinetics were studied in 12 critically ill patients. Antipyrine half life was found to be short (6.5±3.4 h), this did not alter over 4 days of acute illness, although there was a tendency for antipyrine clearance to decrease over that time period. The need for further pharmacological studies in critically ill patients is stressed. © 1979 Springer-Verlag.
引用
收藏
页码：69 / 71
页数：3
相关论文
共 11 条
[1]   DETERMINANTS OF SERUM ANTIPYRINE HALF-LIVES IN PATIENTS WITH LIVER-DISEASE [J].
BRANCH, RA ;
HERBERT, CM ;
READ, AE .
GUT, 1973, 14 (07) :569-573
[2]   IMMEDIATE DECREASE BY HYDROCORTISONE OF PLASMA HALF-LIFE OF ANTIPYRINE [J].
BRECKENRIDGE, A ;
BURKE, CW ;
DAVIES, DS ;
ORME, MLE .
BRITISH JOURNAL OF PHARMACOLOGY, 1973, 47 (02) :434-436
[3]  
BRODIE BB, 1949, J BIOL CHEM, V179, P24
[4]   DRUG UTILIZATION IN A GENERAL INTENSIVE-CARE UNIT [J].
BUCHANAN, N ;
CANE, RD .
INTENSIVE CARE MEDICINE, 1978, 4 (02) :75-77
[5]  
BUCHANAN N, 1977, S AFR MED J, V52, P394
[6]   ALTERED ELIMINATION OF ANTIPYRINE IN PATIENTS WITH ACUTE VIRAL-HEPATITIS [J].
BURNETT, DA ;
BARAK, AJ ;
TUMA, DJ ;
SORRELL, MF .
GUT, 1976, 17 (05) :341-344
[7]  
CUMMING JF, 1976, CLIN PHARMACOL THER, V19, P468
[8]   MECHANISM OF HEPATIC DRUG OXIDATION AND ITS RELATIONSHIP TO INDIVIDUAL DIFFERENCES IN RATES OF OXIDATION IN MAN [J].
DAVIES, DS ;
THORGEIRSSON, SS .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 179 (JUL6) :411-+
[9]  
FRASER HS, 1977, CLIN PHARMACOL THER, V22, P799
[10]  
SOBERMAN R, 1949, J BIOL CHEM, V179, P31
12