COMPARISON OF SIMULTANEOUS MEASUREMENTS OF SYSTOLIC FUNCTION IN THE BABOON BY ELECTROMAGNETIC FLOWMETER AND HIGH FRAME RATE ECG-GATED BLOOD POOL SCINTIGRAPHY

Left ventricle (LV) systolic timing and relative volume variations were simultaneously measured by electromagnetic flowmeter (EMF) and high frame rate ECG-gated blood pool scintigraphy in five baboons. No significant differences (p>0.1, paired t test) were observed in the time (from R wave) to peak aortic flow (maximum LV ejection rate), time to cessation of aortic flow (end-systole) or in the duration of aortic flow (LV-ejection time). A small (~15 msec) but significant systematic difference (p<0.02) was noted in the time to onset of aortic flow. The shape of each scintigraphic time-activity curve during systole was compared to an equivalent curve synthesized from 10 EMF flow profiles obtained in the same baboon. Comparison of these paired curves over systolic ejection yielded an average correlation of r=0.95 (range 0.90-0.99). The ratio of peak flow to stroke volume determined from these data did not differ significantly (p>0.05). In the baboon, quantitative high temporal resolution ECG-gated scintigraphy appears to reflect closely the detailed timing and relative magnitude variation of LV volume during the entire period of systolic ejection. We conclude that the assumptions underlying the scintigraphic method are valid in the baboon during the ejection interval.