IRON-DEFICIENCY PREVENTS LIVER TOXICITY OF 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN

被引：95

作者：

SWEENEY, GD

JONES, KG

COLE, FM

BASFORD, D

KRESTYNSKI, F

机构：

[1] MCMASTER UNIV, DEPT BIOCHEM, HAMILTON L8S 4J9, ONTARIO, CANADA

[2] MCMASTER UNIV, DEPT PATHOL, HAMILTON L8S 4J9, ONTARIO, CANADA

来源：

SCIENCE | 1979年 / 204卷 / 4390期

关键词：

D O I：

10.1126/science.432648

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.

引用

页码：332 / 335

页数：4

共 50 条

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