INSIGHTS INTO THE ROLE OF THE HYDROGEN-BOND AND HYDROPHOBIC EFFECT ON RECOGNITION IN MOLECULARLY IMPRINTED POLYMER SYNTHETIC PEPTIDE RECEPTOR MIMICS

被引：122

作者：

NICHOLLS, IA ^{[1
]}

RAMSTROM, O ^{[1
]}

MOSBACH, K ^{[1
]}

机构：

[1] LUND UNIV,CTR CHEM,DEPT PURE & APPL BIOCHEM,S-22100 LUND,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY A | 1995年 / 691卷 / 1-2期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/0021-9673(94)01067-O

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide antibody combining site mimics prepared by the molecular imprinting of N-Ac-L-Phe-L-Trp-OMe were used as highly efficient ''tailor-made'' chiral stationary phases and for the study of non-ionic non-covalent interaction-based recognition. The effect of water on recognition and the role of the hydrogen bonding and the hydrophobic effect on ligand selectivity are discussed.

引用

页码：349 / 353

页数：5

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