The authors report a case of Clostridium perfringens endophthalmitis occurring after a corneo-limb al injury without intraocular foreign body. The diagnosis was made on CT scan prior to bacteriological identification of the bacteria. Rapid and adapted treatment allowed preservation of the eyeball. The clinical signs, often stereotyped, as well as the combined medical - with systemic antibiotics - and surgical - vitrectomy - treatments are described.