ANTAGONISM OF RESERPINE-INDUCED SUPPRESSION OF SPONTANEOUS MOTOR-ACTIVITY BY STIMULATION OF 5-HT1A RECEPTORS IN RATS

被引:18
|
作者
AHLENIUS, S
SALMI, P
机构
[1] Department of Behavioural Pharmacology, Preclinical Research and Development Laboratories, Astra Arcus AB, Södertälje
来源
PHARMACOLOGY & TOXICOLOGY | 1995年 / 76卷 / 02期
关键词
D O I
10.1111/j.1600-0773.1995.tb00122.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The 5-HT1A and the DA D-2 receptor agonists 8-OH-DPAT (0.05-3.2 mg kg(-1) subcutaneously, -20 min.) and quinpirole (0.08-1.25 mg kg(-1) subcutaneously, -20 min.),respectively, both partially antagonized reserpine-induced (5 mg kg(-1) subcutaneously, -16 hr) suppression of spontaneous motor activity in the rat. Four different aspects of the spontaneous motor activity were recorded in a photocell-equipped open-field (8x8 photocells, 90 mm apart, defining two horizontal planes): locomotor, activity (all photocell counts at the lower level); rearing (all photocell counts at the upper level); forward locomotion (the proportion movements across the arena); peripheral activity (the proportion locomotor activity as picked up by the photocell beam closest to the wall, i.e. 25 mm). As defined by these variables, the pattern of activity produced by 8-OH-DPAT or quinpirole were indistinguishable. The effects produced by 8-OH-DPAT were fully antagonized by the 5-HT, antagonist (-) pindolol (4 mg kg(-1) subcutaneously, -30 min.), but not by the DA D-2 receptor antagonist raclopride (2 mg kg(-1) subcutaneously, -30 min.) nor by the 5-HT2 receptor antagonist ritanserin (2 mg kg(-1) subcutaneously, -30 min.), whereas effects produced by quinpirole were fully antagonized by raclopride (2 mg kg(-1) subcutaneously, -30 min.). Effects produced by quinpirole, but not 8-OH-DPAT, were potentiated by administration of the DA D-1 agonist SKF-38,393 (3 mg kg(-1) subcutaneously, -20 min.). It is concluded that effects by 8-OH-DPAT on spontaneous motor activity in the reserpine treated rat primarily are due to stimulation of postsynaptic S-HT1A receptors.
引用
收藏
页码:149 / 156
页数:8
相关论文
共 50 条
  • [21] DRUG-INDUCED DEFECATION IN RATS - ROLE OF CENTRAL 5-HT1A RECEPTORS
    CROCI, T
    LANDI, M
    BIANCHETTI, A
    MANARA, L
    BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (01) : 203 - 209
  • [22] Reduction in 5-HT1A receptor density, 5-HT1A mRNA expression, and functional correlates for 5-HT1A receptors in genetically defined aggressive rats
    Popova, NK
    Naumenko, VS
    Plyusnina, IZ
    Kulikov, AV
    JOURNAL OF NEUROSCIENCE RESEARCH, 2005, 80 (02) : 286 - 292
  • [23] MOTOR-ACTIVITY IN DECEREBRATE RATS - SPONTANEOUS AND NUTRIENT-INDUCED CHANGES
    JUNQUERA, J
    LANZAGORTASANCHEZ, G
    MEJIAPEREZ, BE
    RACOTTA, R
    AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 247 (06): : R945 - R952
  • [24] The stimulation of 5-HT1A receptors upregulates NGF synthesis in astrocytes
    Semkova, I
    Widing, E
    Schaper, C
    Krieglstein, J
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 356 (04) : 56 - 56
  • [25] Does stimulation of 5-HT1A receptors improve cognition in schizophrenia?
    Meltzer, Herbert Y.
    Sumiyoshi, Tomiki
    BEHAVIOURAL BRAIN RESEARCH, 2008, 195 (01) : 98 - 102
  • [26] EFFECT OF ALPHA-METHYL DOPA ON RESERPINE-INDUCED SUPPRESSION OF MOTOR ACTIVITY AND CONDITIONED AVOIDANCE RESPONSE
    URETSKY, NJ
    SEIDEN, LS
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1969, 168 (01): : 153 - +
  • [27] 5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats
    Rizzo, Stacey J. Sukoff
    Pulicicchio, Claudine
    Malberg, Jessica E.
    Andree, Terrance H.
    Stack, Gary P.
    Hughes, Zoe A.
    Schechter, Lee E.
    Rosenzweig-Lipson, Sharon
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2009, 12 (08): : 1045 - 1053
  • [28] ROLE OF 5-HT1A AND 5-HT2 RECEPTORS IN THE AVERSION INDUCED BY ELECTRICAL-STIMULATION OF INFERIOR COLLICULUS
    MELO, LL
    BRANDAO, ML
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 51 (2-3) : 317 - 321
  • [29] Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation
    Harte, SE
    Kender, RG
    Borszcz, GS
    PAIN, 2005, 113 (03) : 405 - 415
  • [30] Antagonism of serotonin 5-HT1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus
    Engleman, EA
    Robertson, DW
    Thompson, DC
    Perry, KW
    Wong, DT
    JOURNAL OF NEUROCHEMISTRY, 1996, 66 (02) : 599 - 603