A CONVENIENT PROCEDURE FOR THE FORMYLATION OF AMINES AND ALCOHOLS USING CYANOMETHYL FORMATE

被引：29

作者：

DEUTSCH, J ^{[1
]}

NICLAS, HJ ^{[1
]}

机构：

[1] CTR SELECT ORGAN SYNTH BERLIN ADLERSHOF,RUDOWER CHAUSSEE 5,O-1199 BERLIN,GERMANY

来源：

SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 11期

关键词：

D O I：

10.1080/00397919308011251

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple method for the direct formylation of amines using cyanomethyl formate is described. The formylation succeeds in moderate to high yields under mild and neutral conditions. Thus, formamides 2a-f, 2i-m are obtained at room temperature. A chemoselective N-formylation is achieved in the case of ethanolamine. The formylation of nitroanilines and the O-formylation of alcohols only succeeds in the presence of a catalytic amount of imidazole leading to 2g,h and 3a-e, respectively.

引用

页码：1561 / 1568

页数：8

共 24 条

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