CD19 IS A SUBSTRATE OF THE ANTIGEN RECEPTOR-ASSOCIATED PROTEIN-TYROSINE KINASE IN HUMAN B-CELLS

被引：37

作者：

ROIFMAN, CM

KE, S

机构：

[1] Division of Immunology/Allergy, Hospital for Sick Children, Toronto

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.1807

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The B cell antigen receptor, mIg, is part of a multimolecular complex including Igα, Igβ, and CD19. We provide evidence here that upon ligation of mIg CD19 becomes phosphorylated on tyrosine residues. Further, protein tyrosine kinase lyn, which is activated by the antigen receptor, can be readily co-immunoprecipitated with CD19 suggesting this is the enzyme responsible for the antigen receptor mediated tyrosine phosphorylation of CD19. © 1993 Academic Press, Inc.

引用

页码：222 / 225

页数：4

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