INHIBITION OF MEMBRANE POTENTIAL-DEPENDENT AMINO-ACID-TRANSPORT BY DAPTOMYCIN

被引：78

作者：

ALLEN, NE

ALBORN, WE

HOBBS, JN

机构：

[1] Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 12期

关键词：

D O I：

10.1128/AAC.35.12.2639

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.

引用

收藏

页码：2639 / 2642

页数：4

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