Subchronic Feeding Study in Beagle Dogs of N-Methylyprrolidone

被引：12

作者：

Becci, Peter J. ^{[1
]}

Gephart, Larry A. ^{[1
]}

Koschier, Francis J. ^{[1
]}

Johnson, William D. ^{[1
]}

Burnette, Llewellyn W. ^{[2
]}

机构：

[1] Food & Drug Res Labs Inc, POB 107,Route 17C, Waverly, NY 14892 USA

[2] GAF Corp, Wayne, NJ 07470 USA

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1983年 / 3卷 / 02期

关键词：

N-methylpyrrolidone; Beagle dogs; subchronic toxicity;

D O I：

10.1002/jat.2550030206

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The potential toxicity of N-methylpyrrolidone was evaluated following dietary administration for 13 weeks to male and female beagle dogs at dosage levels of 25, 79 and 250 mg per kg body weight per day. Body weight gain and food consumption, hematological and clinical chemical data, and ophthalmic, gross and histopathological examinations were used to study possible toxicological or pathological effects. No statistically significant treatment-related effects that were judged to be biologically meaningful were seen in any parameters of either male or female animals exposed to N-methylpyrrolidone at any dose level. However, a dose-dependent decrease in body weight and increase in platelet count that correlated with increased megakaryocytes was observed. Serum cholesterol in males decreased with increasing doses.

引用

页码：83 / 86

页数：4