IN-VIVO CYTOKINETIC EFFECTS OF RECOMBINANT HUMAN GROWTH-HORMONE (RHGH) IN PATIENTS WITH ADVANCED BREAST-CARCINOMA

被引：0

作者：

BALDINI, E ^{[1
]}

GIANNESSI, PG ^{[1
]}

GARDIN, G ^{[1
]}

ALAMA, A ^{[1
]}

MINUTO, F ^{[1
]}

BARRECA, A ^{[1
]}

CONTE, PF ^{[1
]}

机构：

[1] OSPED S CHIARA,UO ONCOL MED,DIV MED ONCOL,I-56100 PISA,ITALY

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 1994年 / 8卷 / 04期

关键词：

BREAST CANCER CELL PROLIFERATION; KINETIC RECRUITMENT; GROWTH HORMONE; IGF-I;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated the possibility of inducing a kinetic recruitment of breast cancer cells by the in vivo administration of recombinant human Growth Hormone (rhGH). Twelve patients with advanced breast cancer received rhGH Lm. for 2 days immediately before the first course of chemotherapy. The following biological parameters have been evaluated before and 24 hours after rhGH administration: tumor TLI, tumor IGF-I content, serum IGF-I concentration. The mean tumor TLI values before and after rhGH were 1.3% and 2.6% respectively; median tumor and serum IGF-I levels before rhGH were 4.64 ng/g and 63.5 ng/ml respectively; after the administration of rhGH median tumor IGF-I content was 1.8 and median serum IGF-I level was 112 ng/ml. These data suggest that, in vivo, rhGH stimulates breast cancer cell proliferation; the mitogenic stimulus is likely due to the local production of IGF-I induced by rhGH.

引用

页码：113 / 116

页数：4