ANTISTAPHYLOCOCCAL ACTIVITY OF THE FLUOROQUINOLONES CI-960, PD-131628, SPARFLOXACIN, OFLOXACIN AND CIPROFLOXACIN

被引：23
作者：
BARRY, AL [1 ]
FUCHS, PC [1 ]
机构：
[1] ST VINCENT HOSP & MED CTR,PORTLAND,OR 97225
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1991年 / 10卷 / 03期
关键词：
D O I：
10.1007/BF01964451
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Five fluoroquinolones were tested against 300 staphylococci from a wide variety of US medical centers including 150 strains resistant to penicillinase-resistant penicillins (PRP-resistant). Ten ciprofloxacin-resistant strains of PRP-resistant Staphylococcus aureus were relatively resistant to the other fluoroquinolones, but the remaining 290 isolates were susceptible to all five drugs at established or anticipated breakpoint concentrations. The relative potency of the study drugs could be ranked as follows: CI-960 > PD 131628 > sparfloxacin > ciprofloxacin > ofloxacin. All five drugs were bactericidal against PRP-resistant and PRP-susceptible staphylococci.
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页码：168 / 171
页数：4
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