IMMUNOCHEMICAL STUDIES OF MYELIN BASIC-PROTEIN IN SHIVERER MOUSE DEVOID OF MAJOR DENSE LINE OF MYELIN

被引：175
作者：
DUPOUEY, P
JACQUE, C
BOURRE, JM
CESSELIN, F
PRIVAT, A
BAUMANN, N
机构：
[1] HOP SALPETRIERE, CNRS,INSERM,NEUROCHIM LAB,EQUIPE RECH 421,U 134, F-75634 PARIS 13, FRANCE
[2] FAC MED PITIE SALPETRIERE, SERV BIOCHIM, F-75013 PARIS, FRANCE
[3] INSERM, CULTURE TISSU NERVEUX LAB, U 106, F-75014 PARIS, FRANCE
来源：
NEUROSCIENCE LETTERS | 1979年 / 12卷 / 01期
关键词：
D O I：
10.1016/0304-3940(79)91490-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS). Less than 3% of the normal content in MBP is present in a brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to other hypomelinating mutants) stems from the specificity of this genetic lesion, i.e. the lack of basic protein. © 1979.
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页码：113 / 118
页数：6
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