IMMUNOCHEMICAL STUDIES OF MYELIN BASIC-PROTEIN IN SHIVERER MOUSE DEVOID OF MAJOR DENSE LINE OF MYELIN

被引：175

作者：

DUPOUEY, P

JACQUE, C

BOURRE, JM

CESSELIN, F

PRIVAT, A

BAUMANN, N

机构：

[1] HOP SALPETRIERE, CNRS,INSERM,NEUROCHIM LAB,EQUIPE RECH 421,U 134, F-75634 PARIS 13, FRANCE

[2] FAC MED PITIE SALPETRIERE, SERV BIOCHIM, F-75013 PARIS, FRANCE

[3] INSERM, CULTURE TISSU NERVEUX LAB, U 106, F-75014 PARIS, FRANCE

来源：

NEUROSCIENCE LETTERS | 1979年 / 12卷 / 01期

关键词：

D O I：

10.1016/0304-3940(79)91490-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS). Less than 3% of the normal content in MBP is present in a brain extract of Shi/Shi as determined by radioimmunoassay. Indirect immunofluorescence is negative when using specific anti-MBP serum. The importance of Shi/Shi (as compared to other hypomelinating mutants) stems from the specificity of this genetic lesion, i.e. the lack of basic protein. © 1979.

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页码：113 / 118

页数：6

相关论文

共 24 条

[1] FATTY ACID AND LIPID COMPOSITION OF BRAIN OF A MYELIN DEFICIENT MUTANT QUAKING MOUSE [J].

BAUMANN, NA ;

JACQUE, CM ;

POLLET, SA ;

HARPIN, ML .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1968, 4 (03) :340-&

[2]

BIRD TD, 1977, T AM SOC NEUROCHEM, V8, P153

[3] RADIOIMMUNOASSAY FOR MYELIN BASIC-PROTEIN AND ITS USE FOR QUANTITATIVE MEASUREMENTS [J].

COHEN, SR ;

MCKHANN, GM ;

GUARNIERI, M .

JOURNAL OF NEUROCHEMISTRY, 1975, 25 (04) :371-&

[4] STUDIES ON ANTIBODY PRODUCTION .1. A METHOD FOR THE HISTOCHEMICAL DEMONSTRATION OF SPECIFIC ANTIBODY AND ITS APPLICATION TO A STUDY OF THE HYPERIMMUNE RABBIT [J].

COONS, AH ;

LEDUC, EH ;

CONNOLLY, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1955, 102 (01) :49-+

[5] LOCALIZATION OF ENCEPHALITOGENIC BASIC PROTEIN IN INTRAPERIOD LINE OF LAMELLAR MYELIN [J].

DICKINSON, JP ;

JONES, KM ;

APARICIO, SR ;

LUMSDEN, CE .

NATURE, 1970, 227 (5263) :1133-+

[6] MYELIN BASIC-PROTEIN - LOCATION OF MULTIPLE INDEPENDENT ANTIGENIC REGIONS [J].

DRISCOLL, BF ;

KRAMER, AJ ;

KIES, MW .

SCIENCE, 1974, 184 (4132) :73-75

[7] COMPARATIVE-STUDY OF IMMUNOLOGICAL PROPERTIES OF GALACTOSYLDIGLYCERIDE AND GALACTOSYLCERAMIDE INCLUDED WITHIN NATURAL MEMBRANES [J].

DUPOUEY, P ;

BILLECOCQ, A ;

LEFROIT, M .

IMMUNOCHEMISTRY, 1976, 13 (04) :289-294

[8]

GOLDS EE, 1976, J BIOL CHEM, V251, P4729

[9] ISOLATED MYELIN QUANTITATIVELY ADSORBS ANTIBODY TO BASIC-PROTEIN [J].

GUARNIERI, M ;

HIMMELSTEIN, J ;

MCKHANN, GM .

BRAIN RESEARCH, 1974, 72 (01) :172-176

[10] IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF ENCEPHALITOGENIC BASIC PROTEIN IN MYELIN [J].

HERNDON, RM ;

RAUCH, HC ;

EINSTEIN, ER .

IMMUNOLOGICAL COMMUNICATIONS, 1973, 2 (02) :163-172