Richter Transformation in the Brain from Chronic Lymphocytic Leukemia

被引：0

作者：

Ishida, Fumihiro ^{[1
,2
]}

Nakazawa, Hideyuki ^{[2
]}

Takezawa, Yuka ^{[3
]}

Matsuda, Kazuyuki ^{[3
]}

Asano, Naoko ^{[4
]}

Sano, Kenji ^{[4
]}

Sakai, Hitoshi ^{[2
]}

Ito, Toshiro ^{[2
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Biomed Lab Sci, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Internal Med, Div Hematol, Matsumoto, Nagano, Japan

[3] Shinshu Univ Hosp, Cent Lab Dept, Matsumoto, Nagano, Japan

[4] Shinshu Univ, Sch Med, Dept Lab Med, Matsumoto, Nagano, Japan

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2013年 / 53卷 / 02期

关键词：

chronic lymphocytic leukemia; Richter syndrome; central nervous system; immunoglobulin gene;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Richter syndrome (RS) involves the development of an aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL). Diffuse large B-cell lymphoma (DLBCL) is the most common type of RS. Extranodal RS occasionally occurs; however, isolated lesions in the central nervous system (CNS) of RS are rarely seen and the features have not been well described. We describe a Japanese patient who developed isolated involvements of the parenchyma of the CNS as a manifestation of RS two years after the initial diagnosis of CLL. DLBCL in the cerebrum was confirmed to be clonally related to the CLL cells by immunoglobulin heavy chain (IGH) gene analysis, utilizing the identical VH-D-J regions with additional mutations in the IGH variable region.

引用

页码：157 / 160

页数：4

共 26 条

[1] RICHTERS SYNDROME PRESENTING AS PRIMARY CENTRAL NERVOUS-SYSTEM LYMPHOMA - TRANSFORMATION OF AN IDENTICAL CLONE
BAYLISS, KM
KUECK, BD
HANSON, CA
MATTHAEUS, WG
ALMAGRO, UA
[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1990, 93 (01) : 117 - 123
[2] High-dose cytarabine plus high-dose methotrexate versus high-dose methotrexate alone in patients with primary CNS lymphoma: a randomised phase 2 trial
Ferreri, Andres J. M.
Reni, Michele
Foppoli, Marco
Martelli, Maurizio
Pangalis, Gerasimus A.
Frezzato, Maurizio
Cabras, Maria Giuseppina
Fabbri, Alberto
Corazzelli, Gaetano
Ilariucci, Fiorella
Rossi, Giuseppe
Soffietti, Riccardo
Stelitano, Caterina
Vallisa, Daniele
Zaja, Francesco
Zoppegno, Lucia
Aondio, Gian Marco
Avvisati, Giuseppe
Balzarotti, Monica
Brandes, Alba A.
Fajardo, Jose
Gomez, Henry
Guarini, Attilio
Pinotti, Graziella
Rigacci, Luigi
Uhlmann, Catrina
Picozzi, Piero
Vezzulli, Paolo
Ponzoni, Maurilio
Zucca, Emanuele
Caligaris-Cappio, Federico
Cavalli, Franco
[J]. LANCET, 2009, 374 (9700) : 1512 - 1520
[3] Richter syndrome presenting as a solitary cerebellar tumor during first-line treatment for chronic lymphocytic leukemia
Floisand, Yngvar
Delabie, Jan
Fossa, Alexander
Helseth, Eirik
Jacobsen, Eva A.
Rolke, Jurgen
Tjonnfjord, Geir E.
[J]. LEUKEMIA & LYMPHOMA, 2011, 52 (10) : 2007 - 2009
[4] Molecular pathogenesis of chronic lymphocytic leukemia
Gaidano, Gianluca
Foa, Robin
Dalla-Favera, Riccardo
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (10) : 3432 - 3438
[5] Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
Hans, CP
Weisenburger, DD
Greiner, TC
Gascoyne, RD
Delabie, J
Ott, G
Müller-Hermelink, HK
Campo, E
Braziel, RM
Jaffe, ES
Pan, ZG
Farinha, P
Smith, LM
Falini, B
Banham, AH
Rosenwald, A
Staudt, LM
Connors, JM
Armitage, JO
Chan, WC
[J]. BLOOD, 2004, 103 (01) : 275 - 282
[6] Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia
Kikushige, Yoshikane
Ishikawa, Fumihiko
Miyamoto, Toshihiro
Shima, Takahiro
Urata, Shingo
Yoshimoto, Goichi
Mori, Yasuo
Iino, Tadafumi
Yamauchi, Takuji
Eto, Tetsuya
Niiro, Hiroaki
Iwasaki, Hiromi
Takenaka, Katsuto
Akashi, Koichi
[J]. CANCER CELL, 2011, 20 (02) : 246 - 259
[7] Distinctive immunoglobulin VH gene usage in Japanese patients with chronic lymphocytic leukemia
Koiso, H
Yamane, A
Mitsui, T
Matsushima, T
Tsukamoto, N
Murakami, H
Miyawaki, S
Nojima, Y
Karasawa, M
[J]. LEUKEMIA RESEARCH, 2006, 30 (03) : 272 - 276
[8] MAHE B, 1994, NOUV REV FR HEMATOL, V36, P383
[9] IgVH mutational status and clonality analysis of Richter's transformation -: Diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution
Mao, Zhengrong
Quintanilla-Martinez, Leticia
Raffeld, Mark
Richter, Manfred
Krugmann, Jens
Burek, Christof
Hartmann, Elena
Rudiger, Thomas
Jaffe, Elaine S.
Mueller-Hermelink, Hans Konrad
Ott, German
Fend, Falko
Rosenwald, Andreas
[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (10) : 1605 - 1614
[10] A systematic review on Richter syndrome: what is the published evidence?
Molica, Stefano
[J]. LEUKEMIA & LYMPHOMA, 2010, 51 (03) : 415 - 421

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