STUDIES ON EFFECT OF TETRACYCLINE ON TRIGLYCERIDE SYNTHESIS IN EXPERIMENTAL RATS

1. Triglyceride synthesis in rat liver homogenate is stimulated by administration of a single therapeutic dose of tetracycline to the animal prior to sacrifice and maximumstimulation is observed 3 hours after drug-treatment. 2. In the intact tetracycline-treated rat, incorporation of injected 1-14Cpalmitate into liver triglyceride reaches its maximum 3 hours after the drug administration. 3. The release of newly synthesized triglyceride from liver to the circulation system seems to be impaired under the influence of the antibiotic treatment. 4. Tetracycline is unable to stimulate triglyceride synthesis in liver homogenate obtained from adrenalectomized rats treated with this antibiotic. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.