NEUROPHYSIOLOGICAL ASPECTS OF HIPPOCAMPAL NEUROTOXICITY

被引:0
作者
WIEGAND, H
ALTMANN, L
机构
关键词
HIPPOCAMPUS; IN-VITRO; NEUROTOXICITY; CHEMICALS; RISK ASSESSMENT;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Identification and analysis of chemical neurotoxicity in the central nervous system deals with synaptic transmission and plasticity. The hippocampus slice technique rendered a powerful tool for electrophysiological analysis of these events as modulated by neurotoxic chemicals. It does not only allow the detection of potentially harmful compounds, but also the elucidation of their mechanism of action. This might render it possible to analyze the risk of neurotoxic chemicals on the basis of quantitative data, (C) 1994 Intox Press, Inc.
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页码:451 / 458
页数:8
相关论文
共 34 条
[1]   IMPAIRMENT OF LONG-TERM POTENTIATION AND LEARNING FOLLOWING CHRONIC LEAD-EXPOSURE [J].
ALTMANN, L ;
WEINSBERG, F ;
SVEINSSON, K ;
LILIENTHAL, H ;
WIEGAND, H ;
WINNEKE, G .
TOXICOLOGY LETTERS, 1993, 66 (01) :105-112
[2]   ACUTE LEAD-EXPOSURE TRANSIENTLY INHIBITS HIPPOCAMPAL NEURONAL ACTIVITIES INVITRO [J].
ALTMANN, L ;
LOHMANN, H ;
WIEGAND, H .
BRAIN RESEARCH, 1988, 455 (02) :254-261
[3]   LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES IS IMPAIRED FOLLOWING ACUTE LEAD PERFUSION [J].
ALTMANN, L ;
SVEINSSON, K ;
WIEGAND, H .
NEUROSCIENCE LETTERS, 1991, 128 (01) :109-112
[4]   POSTSYNAPTIC INHIBITION BY ADENOSINE IN HIPPOCAMPAL CA3 NEURONS - CO2+-SENSITIVE ACTIVATION OF AN INWARDLY RECTIFYING K+ CONDUCTANCE [J].
ALZHEIMER, C ;
TENBRUGGENCATE, G .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1991, 419 (3-4) :288-295
[5]   EFFECTS OF TRIMETHYLTIN ON EVOKED-POTENTIALS IN MOUSE HIPPOCAMPAL SLICES [J].
ARMSTRONG, DL ;
READ, HL ;
CORK, AE ;
MONTEMAYOR, F ;
WAYNER, MJ .
NEUROTOXICOLOGY AND TERATOLOGY, 1987, 9 (05) :359-362
[6]   EFFECTS OF NEUROTOXICANTS ON SYNAPTIC TRANSMISSION - LESSONS LEARNED FROM ELECTROPHYSIOLOGICAL STUDIES [J].
ATCHISON, WD .
NEUROTOXICOLOGY AND TERATOLOGY, 1988, 10 (05) :393-416
[7]   INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS [J].
BASHIR, ZI ;
BORTOLOTTO, ZA ;
DAVIES, CH ;
BERRETTA, N ;
IRVING, AJ ;
SEAL, AJ ;
HENLEY, JM ;
JANE, DE ;
WATKINS, JC ;
COLLINGRIDGE, GL .
NATURE, 1993, 363 (6427) :347-350
[8]   THE MECHANISM OF INDUCTION OF NMDA RECEPTOR-DEPENDENT LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
COLLINGRIDGE, GL .
EXPERIMENTAL PHYSIOLOGY, 1992, 77 (06) :771-797
[9]   ELECTROPHYSIOLOGICAL ACTIONS OF ACETATE, A METABOLITE OF ETHANOL, ON HIPPOCAMPAL DENTATE GRANULE NEURONS - INTERACTIONS WITH ADENOSINE [J].
CULLEN, N ;
CARLEN, PL .
BRAIN RESEARCH, 1992, 588 (01) :49-57
[10]  
DEFELIPE J, 1988, CAYAL CEREBRAL CORTE