DRUG-RELEASE FROM NEW BIOARTIFICIAL HYDROGEL

被引：11

作者：

GAYET, JC

FORTIER, G

机构：

[1] Laboratoire d'enzymologie appliquee, Groupe de Recherche en Biothdrapeutique Moleculaire, Departement de chimie-biochimie, Universite du Quebec a Montreal, C.P. 8888, Succ. Centre-Ville, Montreal (Quebec)

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY | 1995年 / 23卷 / 05期

关键词：

D O I：

10.3109/10731199509117975

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of high water content (>96%) hydrogels obtained from copolymerisation of bovine serum albumin and poly(ethylene glycol) as a controlled release system has been investigated. Such hydrogels allowed release of soluble and hydrophobic substances, even proteins. Release is shown to occur by a diffusion controlled mechanism, leading to half-lire times of release ranging between 0.8 hour for theophylline and 4.2 hours for lysozyme, when a 2.4 mm thick disc of BSA-PEG (MW of 10000) was used. The effect of the porosity of the hydrogel on the diffusive properties of theophylline and hydrocortisone has been evaluated by varying the molecular weight of the poly(ethylene glycol). It was shown that poly(ethylene glycol) of high molecular weight leads to more porous hydrogels in which the diffusion is faster.

引用

页码：605 / 611

页数：7

共 11 条

[1]

Abuchowsky A, 1981, ENZYMES DRUGS, P367

[2] SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS WITH POLY(ETHYLENE OXIDE), ALBUMIN, AND HEPARIN FOR REDUCED THROMBOGENICITY [J].