INTERACTION BETWEEN MORPHINE AND OPIOID-PEPTIDES AFTER SC ADMINISTRATION

被引：0
作者：
MASZCZYNSKA, I
MIKASZEWSKA, M
KOSSON, D
CARR, DB
SZYFELBEIN, SK
LIPKOWSKI, AW
机构：
[1] MED ACAD WARSAW,DEPT ANESTHESIOL & INTENS CARE,PL-02005 WARSAW,POLAND
[2] MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BOSTON,MA 02114
来源：
REGULATORY PEPTIDES | 1994年
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It is possible that peripheral analgesic targets may enhance central analgesia. We present our preliminary results of selected opioid peptides on morphine (MOR) analgesia. Coinjection of dermorphin with MOR resulted in antinociceptive synergy, whereas morphiceptin coinjected with MOR yielded antinociceptive activity lower than MOR alone. At lower doses of MOR, DADLE strongly potentiates analgesia, but at higher doses of MOR, DADLE inhibits the antinociceptive effect of MOR.
引用
收藏
页码：S243 / S244
页数：2
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