Age and sex-related variations in the time of manifestation of type 1 diabetes mellitus and its chronic complications in children

Aim. To elucidate age and sex-related differences in the time of manifestation of type 1 diabetes mellitus and its chronic complications in children from the analysis of developmental patterns and age of the patients for the substantiation of improved methods of their early diagnostics. Materials and methods. Analysis of the results of comprehensive clinical and instrumental examination of 246 children with DM1 representative of the population of diabetic children in the Tver' region (as per 01.01.2009). Results. Critical periods of DM1 manifestations are identified. The physical development of the childrenis shown to be a function of the duration of DM1 and the number of its chronic complications while the time of their manifestations depends on the age and sex of the patients. Conclusion. The time of DM1 manifestations depends on the age and sex of the patients. and the quality of diabetes compensation which dictates the necessity to optimize screening forthese complications in children.