OVERREPRESENTATION OF THE V-KAPPA(IV) SUBGROUP IN LIGHT-CHAIN DEPOSITION DISEASE

被引：69

作者：

DENOROY, L ^{[1
]}

DERET, S ^{[1
]}

AUCOUTURIER, P ^{[1
]}

机构：

[1] CNRS,SERV CENT ANAL,F-69390 VERNAISON,FRANCE

来源：

IMMUNOLOGY LETTERS | 1994年 / 42卷 / 1-2期

关键词：

LIGHT CHAIN DEPOSITION DISEASE; MYELOMA; BENCE-JONES PROTEIN; IMMUNOGLOBULIN LIGHT CHAIN;

D O I：

10.1016/0165-2478(94)90036-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The variability subgroup of human monoclonal kappa chains purified from urine in 3 consecutive patients with myeloma associated light chain deposition disease was determined from amino acid sequences of their first framework regions (FR1). N-glycosylation was searched for by N-glycosidase F treatment. These data together with our previously published results, ind: Icate the pathogenic potential of the rare V kappa(IV) subgroup and confirm the absence of detectable serum and urine free monoclonal light chains when they are N-glycosylated.

引用

页码：63 / 66

页数：4

共 15 条

[1] AMINO-ACID-SEQUENCE OF K-SCI, THE BENCE-JONES PROTEIN ISOLATED FROM A PATIENT WITH LIGHT CHAIN DEPOSITION DISEASE [J].