STRUCTURE OF CHICKEN ANNEXIN-V AT 2.25-ANGSTROM RESOLUTION

The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 angstrom. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.