STRUCTURE OF CHICKEN ANNEXIN-V AT 2.25-ANGSTROM RESOLUTION

被引：60
作者：
BEWLEY, MC
BOUSTEAD, CM
WALKER, JH
WALLER, DA
机构：
[1] UNIV LEEDS,DEPT BIOCHEM & MOLEC BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND
[2] MAX PLANCK INST BIOCHEM,W-8033 MARTINSRIED,GERMANY
来源：
BIOCHEMISTRY | 1993年 / 32卷 / 15期
基金：
英国惠康基金;
关键词：
D O I：
10.1021/bi00066a011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The crystal structure of chicken annexin V has been solved by molecular replacement and refined at 2.25 angstrom. The final R factor is 19.7% with good geometry. The chicken annexin V structure is very similar to the human annexin V structure, with four similar domains each containing five helices. The structure includes three calcium ions in domains I, II, and IV, each bound by the characteristic K-G-X-G-T-(38 residues)-D/E motif. In view of the structural similarity between human and chicken annexin V, we suggest that they have a common vital function which developed early in evolutionary history.
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页码：3923 / 3929
页数：7
相关论文
共 61 条
[1]   A ROLE FOR CALPACTIN IN CALCIUM-DEPENDENT EXOCYTOSIS IN ADRENAL CHROMAFFIN CELLS [J].
ALI, SM ;
GEISOW, MJ ;
BURGOYNE, RD .
NATURE, 1989, 340 (6231) :313-315
[2]  
ANDREE HAM, 1992, J BIOL CHEM, V267, P17907
[3]   AMINO-ACID-SEQUENCE ANALYSIS OF THE ANNEXIN SUPERGENE FAMILY OF PROTEINS [J].
BARTON, GJ ;
NEWMAN, RH ;
FREEMONT, PS ;
CRUMPTON, MJ .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 198 (03) :749-760
[4]   MEMBRANE-BOUND ANNEXIN-V ISOFORMS (CABP33 AND CABP37) AND ANNEXIN-VI IN BOVINE-TISSUES BEHAVE LIKE INTEGRAL MEMBRANE-PROTEINS [J].
BIANCHI, R ;
GIAMBANCO, I ;
CECCARELLI, P ;
PULA, G ;
DONATO, R .
FEBS LETTERS, 1992, 296 (02) :158-162
[5]   ISOLATION AND CHARACTERIZATION OF 2 NOVEL CALCIUM-DEPENDENT PHOSPHOLIPID-BINDING PROTEINS FROM BOVINE LUNG [J].
BOUSTEAD, CM ;
WALKER, JH ;
GEISOW, MJ .
FEBS LETTERS, 1988, 233 (02) :233-238
[6]   CRYSTALLIZATION AND PRELIMINARY-X-RAY STUDIES OF ANNEXIN-IV (ENDONEXIN), A CALCIUM-DEPENDENT PHOSPHOLIPID-BINDING PROTEIN [J].
BOUSTEAD, CM ;
WALKER, JH ;
KENNEDY, D ;
WALLER, DA .
FEBS LETTERS, 1991, 279 (02) :187-189
[7]  
BOUSTEAD CM, IN PRESS BIOCH J
[8]   STRUCTURE OF SOLUBLE AND MEMBRANE-BOUND HUMAN ANNEXIN-V [J].
BRISSON, A ;
MOSSER, G ;
HUBER, R .
JOURNAL OF MOLECULAR BIOLOGY, 1991, 220 (02) :199-203
[9]   THE ANNEXIN FAMILY OF CALCIUM-BINDING PROTEINS [J].
BURGOYNE, RD ;
GEISOW, MJ .
CELL CALCIUM, 1989, 10 (01) :1-10
[10]   CALCIUM-CHANNEL ACTIVITY OF PURIFIED HUMAN SYNEXIN AND STRUCTURE OF THE HUMAN SYNEXIN GENE [J].
BURNS, AL ;
MAGENDZO, K ;
SHIRVAN, A ;
SRIVASTAVA, M ;
ROJAS, E ;
ALIJANI, MR ;
POLLARD, HB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (10) :3798-3802
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