CHROMOSOME-9 SHORT ARM DELETIONS IN MALIGNANT DISEASES

被引：10

作者：

EINHORN, S

HEYMAN, M

机构：

[1] Division of Experimental Oncology, Radiumhemmet, Karolinska Hospital

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 11卷 / 3-4期

关键词：

CHROMOSOME-9; INTERFERON; TUMOR SUPPRESSOR GENES;

D O I：

10.3109/10428199309086995

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Deletions of 9p21-22, that frequently include the alpha-, beta- and omega-IFN gene cluster, are common in malignant diseases such as acute lymphocytic leukemia, malignant melanoma and malignant glioma. There is also evidence to support the role of a gene(s) on chromosome 9p21 in predisposition for familial malignant melanoma. Although initial studies implicated that the IFN genes could serve as tumor suppressor genes, there is now data, mainly based on estimations of minimum region of overlap for the deletions, indicating that the relevant tumor suppressor gene is located centromeric of the alpha-, beta-, omega-IFN gene cluster.

引用

页码：191 / 196

页数：6

共 9 条

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