ESTRADIOL RECEPTORS IN COMBINATION WITH NEU OR MYC ONCOGENE AMPLIFICATIONS MIGHT DEFINE NEW SUBTYPES OF BREAST-CANCER

被引:12
作者
BOLUFER, P
MOLINA, R
RUIZ, A
HERNANDEZ, M
VAZQUEZ, C
LLUCH, A
机构
[1] INST VALENCIANO ONCOL,VALENCIA,SPAIN
[2] HOSP LA FE,DEPT PATHOL,E-46009 VALENCIA,SPAIN
[3] UNIV HOSP VALENCIA,FAC MED,DEPT MED ONCOL,VALENCIA,SPAIN
关键词
ONCOGENES; NEU; MYC; ESTRADIOL RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; BREAST CANCER; PROGNOSIS FACTORS;
D O I
10.1016/0009-8981(94)90233-X
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Amplifications of neu and c-myc were evaluated in 218 and 145 breast cancers (BC), respectively. Oncogene amplifications were determined for the most part by Southern blot. An association between the proportion of nodes affected and the intensity of neu amplification in estadiol receptor negative (ER-) BC was found (P = 0.028), which was confirmed by the multi-factor analysis of variance (P = 0.05). A significantly greater incidence in neu amplifications among BC with metastases was also found (P = 0.031). A strong association (P = 0.01) between the neu and myc amplification was observed. There is a strong association between myc amplification and ER- BC (P < 0.01). It is concluded that (1) the combination ER-with neu amplification might define a new group of more aggressive BC, as is suggested by their associated nodal involvement; (2) the linkage of myc amplifications with ER- BC and high grade of neu amplification might reflect a trait of tumor aggressivity.
引用
收藏
页码:107 / 122
页数:16
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