MUTATION CAUSING OVERPRODUCTION OF THE SHORT PEPTIDE COMPONENT-GAMMA OF PENICILLIN-BINDING PROTEIN-1BS OF ESCHERICHIA-COLI

被引：0

作者：

ISHINO, F ^{[1
]}

ITO, Y ^{[1
]}

UENO, S ^{[1
]}

TAMAKI, S ^{[1
]}

MATSUHASHI, M ^{[1
]}

机构：

[1] UNIV TOKYO, INST APPL MICROBIOL, 1-1-1 YAYOI, BUNKYO KU, TOKYO 113, JAPAN

来源：

JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY | 1990年 / 36卷 / 03期

关键词：

D O I：

10.2323/jgam.36.163

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An Escherichia coli mutant was isolated which overproduces component γ of penicillin-binding protein (PBP)-lBs. The mutant formed normal amounts of components α and its proteolytic product β. The mutation was located in mrcB, the structural gene coding for PBP-lBα and γ. The overproduction of the mutant-type PBP-lBγ was caused by an alteration of one nucleotide which changed the GGC coding for glycine at residue 8 from the N-terminal of PBP-lBγ to GAC coding for aspartate. © 1990, Applied Microbiology, Molecular and Cellular Biosciences Research Foundation. All rights reserved.

引用

页码：163 / 169

页数：7

共 12 条

[11] CONVERSION OF THE ALPHA-COMPONENT OF PENICILLIN-BINDING PROTEIN-1B TO THE BETA-COMPONENT IN ESCHERICHIA-COLI
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[12] THERMOSENSITIVE MUTATION IN ESCHERICHIA-COLI SIMULTANEOUSLY CAUSING DEFECTS IN PENICILLIN-BINDING PROTEIN-1BS AND IN ENZYME-ACTIVITY FOR PEPTIDOGLYCAN SYNTHESIS INVITRO
TAMAKI, S
NAKAJIMA, S
MATSUHASHI, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5472 - 5476

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