GENERATION OF SUPEROXIDE ANION AND HYDROGEN-PEROXIDE INDUCED BY NIFURTIMOX IN TRYPANOSOMA-CRUZI

被引：126
作者：
DOCAMPO, R [1 ]
STOPPANI, AOM [1 ]
机构：
[1] UNIV BUENOS AIRES, FAC MED, INST QUIM BIOL, BUENOS AIRES 1121, ARGENTINA
来源：
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1979年 / 197卷 / 01期
关键词：
D O I：
10.1016/0003-9861(79)90251-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Addition of nifurtimox (a nitrofuran derivative) to Trypanosoma cruzi culture (epimastigote) forms induced an increase in the respiratory rate and the release of H2O2 from the whole cells to the suspending medium. Growth-inhibiting concentrations of nifurtimox were able to stimulate O2{minus sign, dot below} production by the T. cruzi mitochondrial fraction supplemented with NADH (or succinate), and also to enhance the generation of O2{minus sign, dot below} by the microsomal fraction with NADPH as reductant. © 1979.
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收藏
页码：317 / 321
页数：5
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