REACTION OF 3',5'-DI-O-ACETYL-2'-DEOXYINOSINE WITH THE CHLORINATING AGENT P(PH)3-CCL4 - SYNTHESIS OF THE 6-CHLORODERIVATIVE AND OF A NEW BASE LINKED DIMER, USEFUL INTERMEDIATE TO N-15-1-LABELED 2'-DEOXYINOSINE

被引：17

作者：

DENAPOLI, L ^{[1
]}

MESSERE, A ^{[1
]}

MONTESARCHIO, D ^{[1
]}

PICCIALLI, G ^{[1
]}

SANTACROCE, C ^{[1
]}

VARRA, M ^{[1
]}

机构：

[1] UNIV NAPLES,DIPARTIMENTO CHIM ORGAN & BIOL,I-80134 NAPLES,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 08期

关键词：

D O I：

10.1039/p19940000923

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 3',5'-di-O-acetyl-2'-deoxyinosine 1 with PPh(3)-CCl4 in the presence of catalytic 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) afforded 6-chloro-9-(2'-deoxy-3'.5'-di-O-acenyl-beta-D-ribofuranosyl)purine 3. Use of an excess of DBU gave the new dimeric bipurine 5 (90%) which proved to be a useful intermediate for obtaining, in one step. [N-15-1]-2'-deoxyinosine.

引用

页码：923 / 925

页数：3

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