STUDIES ON THE SUBSTRATE-SPECIFICITY OF CLAVAMINIC ACID SYNTHASE AND ASSOCIATED ENZYMES

被引：2

作者：

ELSON, SW ^{[1
]}

BAGGALEY, KH ^{[1
]}

HOLLAND, S ^{[1
]}

NICHOLSON, NH ^{[1
]}

SIME, JT ^{[1
]}

WORONIECKI, SR ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80417-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fifteen structural analogues of proclavaminic acid have been synthesised and incubated with enzyme preparations from Streptomyces clavuligerus in order to test the substrate specificity of the enzymes responsible for converting monocyclic beta-lactams to bicyclic beta-lactams.

引用

页码：1503 / 1508

页数：6

共 11 条

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