PRODUCTION OF INTERLEUKIN-8 BY CULTURED SYNOVIAL-CELLS IN RESPONSE TO INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR

被引：0
|
作者：
HIROTA, K
AKAHOSHI, T
ENDO, H
KONDO, H
KASHIWAZAKI, S
机构：
[1] KITASATO UNIV,SCH MED,DEPT INTERNAL MED,1-15-1 KITASATO,SAGAMIHARA,KANAGAWA 228,JAPAN
[2] TOKYO WOMENS MED COLL,INST RHEUMATOL,SHINJUKU KU,TOKYO 162,JAPAN
来源：
RHEUMATOLOGY INTERNATIONAL | 1992年 / 12卷 / 01期
关键词：
INTERLEUKIN-8; SYNOVIAL CELLS; RHEUMATOID ARTHRITIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Both interleukin 1-alpha (IL-1-alpha) and tumor necrosis factor-alpha (TNF-alpha) stimulated the production of interleukin 8 (IL-8) by synovial cells in time and dose dependent manners. Enhanced chemotactic activity of polymorphonuclear cells (PMN) in culture supernatants of synovial cells was neutralized with anti-IL-8 antibody, thus showing synovial cells to be capable of secreting IL-8 which may contribute to PMN accumulation in rheumatoid inflamed joints.
引用
收藏
页码：13 / 16
页数：4
相关论文
共 50 条
  • [1] PRODUCTION OF INTERLEUKIN-8 BY HUMAN DERMAL FIBROBLASTS AND KERATINOCYTES IN RESPONSE TO INTERLEUKIN-1 OR TUMOR NECROSIS FACTOR
    LARSEN, CG
    ANDERSON, AO
    OPPENHEIM, JJ
    MATSUSHIMA, K
    IMMUNOLOGY, 1989, 68 (01) : 31 - 36
  • [2] INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR
    HERZOG, C
    MULLER, W
    ZEITSCHRIFT FUR RHEUMATOLOGIE, 1987, 46 (05): : 213 - 219
  • [3] EXPRESSION OF MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR IN RHEUMATOID-ARTHRITIS - REGULATION OF ITS PRODUCTION IN SYNOVIAL-CELLS BY INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR
    AKAHOSHI, T
    WADA, C
    ENDO, H
    HIROTA, K
    HOSAKA, S
    TAKAGISHI, K
    KONDO, H
    KASHIWAZAKI, S
    MATSUSHIMA, K
    ARTHRITIS AND RHEUMATISM, 1993, 36 (06): : 762 - 771
  • [4] STIMULATION OF THE BIOSYNTHESIS OF INTERLEUKIN-8 BY INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN CULTURED HUMAN CHORIONIC CELLS
    ITO, A
    NAKAMURA, T
    UCHIYAMA, T
    HIROSE, K
    HIRAKAWA, S
    SASAGURI, Y
    MORI, Y
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1994, 17 (11) : 1463 - 1467
  • [5] Interleukin-8 production by human monocytic cells in response to staphylococcal exotoxins is direct and independent of interleukin-1 and tumor necrosis factor-α
    Krakauer, T
    JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (02): : 573 - 577
  • [6] THE EFFECTS OF TUMOR-NECROSIS-FACTOR ON THE PRODUCTION OF INTERLEUKIN-1 BY MACROPHAGES
    HOFFMAN, MK
    LYMPHOKINE RESEARCH, 1986, 5 (04): : 255 - 260
  • [7] Regulation of interleukin-1α and tumor necrosis factor-α-induced interleukin-8 production by amnion-derived (WISH) cells
    Kawano, Y.
    Furukawa, Y.
    Karakida, S.
    Kira, N.
    Ishii, T.
    Narahara, H.
    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 2012, 39 (01): : 43 - 48
  • [8] INDUCTION OF INTERLEUKIN-6 PRODUCTION BY INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR IN HUMAN HEPATOMA-CELLS
    KOHDA, H
    ONO, M
    TORIMOTO, Y
    OHHIRA, M
    MIZUNO, M
    TANAKA, T
    SEKIYA, C
    NAMIKI, M
    GASTROENTEROLOGIA JAPONICA, 1992, 27 (05): : 685 - 685
  • [9] TUMOR-NECROSIS-FACTOR, INTERFERON-TAU, INTERLEUKIN-1 AND INTERLEUKIN-8, INDUCE NEUTROPHIL MIGRATION INVIVO BY INDIRECT MECHANISMS
    CUNHA, FQ
    RIBEIRO, RA
    FACCIOLI, LH
    SOUZA, GEP
    FERREIRA, SH
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (06) : 2245 - 2246
  • [10] INTERLEUKIN-1, TUMOR-NECROSIS-FACTOR AND THEIR SPECIFIC INHIBITORS
    DAYER, JM
    BURGER, D
    EUROPEAN CYTOKINE NETWORK, 1994, 5 (06) : 563 - 571
12345