2ND-GENERATION AUXILIARY FOR THE ASYMMETRIC ADDITION OF METALATED TETRAHYDROISOQUINOLINES TO ALDEHYDES

被引：19

作者：

ZHANG, PS ^{[1
]}

GAWLEY, RE ^{[1
]}

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 21期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)79567-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selectivity of asymmetric addition of tetrahydroisoquinolyloxazoline Grignard reagents to aldehydes has now been improved to 78-82% ds through the use of a camphor-derived auxiliary. The new auxiliary has broad applicability, with overall yields of chemically and diastereomerically pure addition products now in the 50-58% range.

引用

页码：2945 / 2948

页数：4

共 20 条

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