FATE OF 2-PHENETHYLAMINO-1-PHENYLETHANOL,2-14C IN RATS

被引：1

作者：

WELLS, JN

ANDRUS, WG

机构：

[1] The Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, Lafayette, Indiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 12期

关键词：

2‐Phenethylamino‐1‐phenylethanol—toxicity; in vivo inhibition and metabolic fate; LD[!sub]50[!/sub] determination‐2‐phenethyl‐amino‐1‐phenylethanol;

D O I：

10.1002/jps.2600581234

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The fate of 2‐phenethylamino‐1‐phenylethanol,2‐14C was determined following i.p. administration to rats. Little if any radioactivity was detected in tissue samples 2 days after dosage. The radioactivity was eliminated primarily in the urine. Recovery amounted to 91 % in the urine and 6.8 % in the feces after 3 days. The radioactivity in the urine was due to the administered compound. LD50 determination and in vivo MAO inhibition are also reported. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1553 / &

共 7 条

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