Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma

被引：13
作者：
Nault, Jean-Charles [1 ,2 ,3 ,4 ,5 ]
Datta, Shalini [1 ,2 ,3 ,4 ]
Imbeaud, Sandrine [1 ,2 ,3 ,4 ]
Franconi, Andrea [1 ,2 ,3 ,4 ]
Zucman-Rossi, Jessica [1 ,2 ,3 ,4 ,6 ]
机构：
[1] INSERM, UMR 1162, Genom Fonct Tumeurs Solides, Equipe Labellisee Ligue Canc, F-75010 Paris, France
[2] Univ Paris 05, Labex Immuno Oncol, Sorbonne Paris Cite, Fac Med, Paris, France
[3] Univ Paris 13, Sorbonne Paris Cite, UFR SMBH, F-93000 Bobigny, France
[4] Univ Paris Diderot, F-75013 Paris, France
[5] Hop Univ Paris Seine St Denis, AP HP, Site Jean Verdier, Serv Hepatol,Pole Activite Cancerol Specialisee, F-93143 Bondy, France
[6] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 02期
关键词：
Adeno-associated virus type 2; gene therapy; hepatocellular carcinoma; insertional mutagenesis; TERT;
D O I：
10.1080/23723556.2015.1095271
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adeno-associated virus type 2 (AAV2) is a defective DNA virus that was previously considered to be nonpathogenic. We identified somatic AAV2 integration in a subset of 11 hepatocellular carcinomas (HCC) that mainly developed in normal liver without known etiology through recurrent insertional mutagenesis in cancer driver genes such as telomerase reverse transcriptase (TERT), cyclin A2 (CCNA2), cyclin E1 (CCNE1), tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), and lysine (K)-specific methyltransferase 2B (KMT2B).
引用
收藏
页数：3
相关论文
共 10 条
  • [1] AAV vector integration sites in mouse hepatocellular carcinoma
    Donsante, Anthony
    Miller, Daniel G.
    Li, Yi
    Vogler, Carole
    Brunt, Elizabeth M.
    Russell, David W.
    Sands, Mark S.
    [J]. SCIENCE, 2007, 317 (5837) : 477 - 477
  • [2] Adeno-associated virus: from defective virus to effective vector
    Goncalves, Manuel A. F. V.
    [J]. VIROLOGY JOURNAL, 2005, 2 (1)
  • [3] Why do viruses cause cancer? Highlights of the first century of human tumour virology
    Moore, Patrick S.
    Chang, Yuan
    [J]. NATURE REVIEWS CANCER, 2010, 10 (12) : 878 - 889
  • [4] Adenovirus-Associated Virus Vector-Mediated Gene Transfer in Hemophilia B
    Nathwani, Amit C.
    Tuddenham, Edward G. D.
    Rangarajan, Savita
    Rosales, Cecilia
    McIntosh, Jenny
    Linch, David C.
    Chowdary, Pratima
    Riddell, Anne
    Pie, Arnulfo Jaquilmac
    Harrington, Chris
    O'Beirne, James
    Smith, Keith
    Pasi, John
    Glader, Bertil
    Rustagi, Pradip
    Ng, Catherine Y. C.
    Kay, Mark A.
    Zhou, Junfang
    Spence, Yunyu
    Morton, Christopher L.
    Allay, James
    Coleman, John
    Sleep, Susan
    Cunningham, John M.
    Srivastava, Deokumar
    Basner-Tschakarjan, Etiena
    Mingozzi, Federico
    High, Katherine A.
    Gray, John T.
    Reiss, Ulrike M.
    Nienhuis, Arthur W.
    Davidoff, Andrew M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (25) : 2357 - 2365
  • [5] High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
    Nault, Jean Charles
    Mallet, Maxime
    Pilati, Camilla
    Calderaro, Julien
    Bioulac-Sage, Paulette
    Laurent, Christophe
    Laurent, Alexis
    Cherqui, Daniel
    Balabaud, Charles
    Zucman Rossi, Jessica
    [J]. NATURE COMMUNICATIONS, 2013, 4
  • [6] Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
    Nault, Jean-Charles
    Datta, Shalini
    Imbeaud, Sandrine
    Franconi, Andrea
    Mallet, Maxime
    Couchy, Gabrielle
    Letouze, Eric
    Pilati, Camilla
    Verret, Benjamin
    Blanc, Jean-Frederic
    Balabaud, Charles
    Calderaro, Julien
    Laurent, Alexis
    Letexier, Melanie
    Bioulac-Sage, Paulette
    Calvo, Fabien
    Zucman-Rossi, Jessica
    [J]. NATURE GENETICS, 2015, 47 (10) : 1187 - +
  • [7] Mechanisms of HBV-related hepatocarcinogenesis
    Neuveut, Christine
    Wei, Yu
    Buendia, Marie Annick
    [J]. JOURNAL OF HEPATOLOGY, 2010, 52 (04) : 594 - 604
  • [8] Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
    Schulze, Kornelius
    Imbeaud, Sandrine
    Letouze, Eric
    Alexandrov, Ludmil B.
    Calderaro, Julien
    Rebouissou, Sandra
    Couchy, Gabrielle
    Meiller, Clement
    Shinde, Jayendra
    Soysouvanh, Frederic
    Calatayud, Anna-Line
    Pinyol, Roser
    Pelletier, Laura
    Balabaud, Charles
    Laurent, Alexis
    Blanc, Jean-Frederic
    Mazzaferro, Vincenzo
    Calvo, Fabien
    Villanueva, Augusto
    Nault, Jean-Charles
    Bioulac-Sage, Paulette
    Stratton, Michael R.
    Llovet, Josep M.
    Zucman-Rossi, Jessica
    [J]. NATURE GENETICS, 2015, 47 (05) : 505 - U106
  • [9] Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
    Sung, Wing-Kin
    Zheng, Hancheng
    Li, Shuyu
    Chen, Ronghua
    Liu, Xiao
    Li, Yingrui
    Lee, Nikki P.
    Lee, Wah H.
    Ariyaratne, Pramila N.
    Tennakoon, Chandana
    Mulawadi, Fabianus H.
    Wong, Kwong F.
    Liu, Angela M.
    Poon, Ronnie T.
    Fan, Sheung Tat
    Chan, Kwong L.
    Gong, Zhuolin
    Hu, Yujie
    Lin, Zhao
    Wang, Guan
    Zhang, Qinghui
    Barber, Thomas D.
    Chou, Wen-Chi
    Aggarwal, Amit
    Hao, Ke
    Zhou, Wei
    Zhang, Chunsheng
    Hardwick, James
    Buser, Carolyn
    Xu, Jiangchun
    Kan, Zhengyan
    Dai, Hongyue
    Mao, Mao
    Reinhard, Christoph
    Wang, Jun
    Luk, John M.
    [J]. NATURE GENETICS, 2012, 44 (07) : 765 - U188
  • [10] Genetic Landscape and Biomarkers of Hepatocellular Carcinoma
    Zucman-Rossi, Jessica
    Villanueva, Augusto
    Nault, Jean-Charles
    Llovet, Josep M.
    [J]. GASTROENTEROLOGY, 2015, 149 (05) : 1226 - +
1