Synthesis of some 4-substituted 1-(4-hydroxybutyl)pyrazolo-[3,4-d]pyrimidine analogues of 9-(4-hydroxybutyl)guanine (HBG)

被引:0
|
作者
Taha, ML [1 ]
Lazrek, HB [1 ]
机构
[1] UNIV CADI AYAD, FAC SCI SEMLALIA, CHIM BIOORGAN LAB, MARRAKECH, MOROCCO
来源
BULLETIN DES SOCIETES CHIMIQUES BELGES | 1995年 / 104卷 / 11期
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
xThe chemical synthesis of some 4-substituted 1-(4-hydroxybutyl)pyrazolo [3,4-d]pyrimidines was described. Using solid-liquid phase transfer catalysis, the 4-alkylthio-1-(4-acetoxybutyl)pyrazolo[3,4-d]pyrimidines 3a-c were regioselectively prepared in good yields. The influence of the solvent, the catalyst and the base on yields of the reaction was investigated. The carboacyclonucleoside 4-methylthio-1-(4-hydroxybutyl)pyrazolo[3,4-d]pyrimidine a was served as the precursor for the preparation of the 4-methylamino 4d, 4-dimethylamino 4e, 4-benzylamino 4f, 4-amino 4g and 4-methoxy 4h analogues.
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页码:647 / 652
页数:6
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