TISSUE FACTOR EXPRESSION CORRELATES WITH HISTOLOGICAL GRADE IN HUMAN PANCREATIC-CANCER

被引：206
作者：
KAKKAR, AK
LEMOINE, NR
SCULLY, MF
TEBBUTT, S
WILLIAMSON, RCN
机构：
[1] ROYAL POSTGRAD MED SCH,DEPT SURG,LONDON,ENGLAND
[2] ROYAL POSTGRAD MED SCH,IMPERIAL CANC RES FUND,ONCOL UNIT,LONDON,ENGLAND
[3] THROMBOSIS RES INST,LONDON SW3 6LR,ENGLAND
来源：
BRITISH JOURNAL OF SURGERY | 1995年 / 82卷 / 08期
关键词：
D O I：
10.1002/bjs.1800820831
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The transmembrane cellular receptor tissue factor (TF) is the primary initiator of the coagulation cascade in man. Expression of TF was determined in 55 specimens of ductal adenocarcinoma of the pancreas and was found to correlate strongly with the degree of histological differentiation. A significant linear trend was observed with stronger immunoreactivity observed in poorly differentiated tumours ((2)(chi) = 6.69, P = 0.0098). No TF staining was seen in pancreatic samples from normal controls (n = 18). As expression of TF may be associated with tumour progression, its analysis could provide useful prognostic information in patients with pancreatic malignancy.
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页码：1101 / 1104
页数：4
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