PREPARATION OF ENANTIOMERICALLY PURE TRANS-2-(1-NAPHTHYL)CYCLOHEXAN-1-OL AND CIS-2-(1-NAPHTHYL)CYCLOHEXAN-1-OL

被引：10

作者：

TAKAHASHI, M ^{[1
]}

OGASAWARA, K ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 98077,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00206-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lipase-mediated treatment of racemic trans-2-(1-naphthyl)cyclohexan-1-ol with vinyl acetate allows clear-cut enantiospecific kinetic acetylation to give (+)-(1R,2S)-acetate in excellent chemical and enantiomeric excesses leaving (+)-(1S,2R)-alcohol in an excellent enantiomeric purity and excellent recovery. The enantiomerically pure alcohol obtained is transformed into the diastereomeric alcohol neatly via the Mitsunobu inversion reaction.

引用

页码：1617 / 1620

页数：4

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