SPONTANEOUS CYCLIZATION OF THE ASPARTIC-ACID SIDE-CHAIN TO THE SUCCINIMIDE DERIVATIVE

被引：26

作者：

CAPASSO, S ^{[1
]}

MAZZARELLA, L ^{[1
]}

SICA, F ^{[1
]}

ZAGARI, A ^{[1
]}

SALVADORI, S ^{[1
]}

机构：

[1] UNIV FERRARA,DEPT PHARMACEUT SCI,I-44100 FERRARA,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 12期

关键词：

D O I：

10.1039/c39920000919

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

At equilibrium in acidic solution the succinimide derivative, formed by cyclization reaction of the Asp side chain, predominates; at a pH close to the apparent pK(a) of the Asp residue this reaction is relatively fast with a t1/2 of a few days.

引用

页码：919 / 921

页数：3

共 11 条

[1]

[Anonymous], 1984, PRACTICE PEPTIDE SYN

[2]

CAPASSO S, 1989, INT J PEPT PROT RES, V33, P124

[3]

CAPASSO S, 1989, Peptide Research, V2, P195

[4] SOLID-STATE CONFORMATIONS OF AMINOSUCCINYL PEPTIDES - CRYSTAL-STRUCTURE OF TERT-BUTYLOXYCARBONYL-L-LEUCYL-L-AMINOSUCCINYL-L-PHENYLALANINAMIDE [J].

CAPASSO, S ;

MAZZARELLA, L ;

SICA, F ;

ZAGARI, A .

BIOPOLYMERS, 1989, 28 (01) :139-147

[5]

EDE N J, 1991, Peptide Research, V4, P171

[6]

GEIGER T, 1987, J BIOL CHEM, V262, P785

[7] IDENTIFICATION OF THE ASPARTIMIDE STRUCTURE IN A PREVIOUSLY-REPORTED PEPTIDE [J].

ROBSON, VMJ ;

RAE, ID ;

NG, F .

BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1990, 371 (05) :423-431

[8]

SALVADORI S, 1981, EUR J MED CHEM, V16, P229

[9]

SZABO Z. G., 1969, COMPREHENSIVE CHEM K, V2, P1

[10] SEQUENCE AND STRUCTURE DETERMINANTS OF THE NONENZYMATIC DEAMIDATION OF ASPARAGINE AND GLUTAMINE RESIDUES IN PROTEINS [J].

WRIGHT, HT .

PROTEIN ENGINEERING, 1991, 4 (03) :283-294

← 1 2 →