AN ANTIVIRAL SOLUBLE FORM OF THE LDL RECEPTOR-INDUCED BY INTERFERON

被引：63

作者：

FISCHER, DG ^{[1
]}

TAL, N ^{[1
]}

NOVICK, D ^{[1
]}

BARAK, S ^{[1
]}

RUBINSTEIN, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT MOLEC GENET & VIROL,IL-76100 REHOVOT,ISRAEL

来源：

SCIENCE | 1993年 / 262卷 / 5131期

关键词：

D O I：

10.1126/science.8211145

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interferons, which induce several intracellular antiviral proteins, also induce an extracellular soluble protein that inhibits vesicular stomatitis virus (VSV) infection. This 28-kilodalton soluble protein was purified to homogeneity and identified by protein sequencing as the ligand-binding domain of the human 160-kilodalton low density lipoprotein receptor (LDLR). The existence of an antiviral soluble LDLR was confirmed by immunoaffinity chromatography with monoclonal antibody to LDLR. This soluble receptor mediates most of the interferon-triggered antiviral activity against VSV, apparently by interfering with virus assembly or budding, and not by inhibiting virus attachment to cells.

引用

页码：250 / 253

页数：4

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