COMPUTER MODELING OF THE OXYGEN-SUPPLY AND DEMAND OF CELLS OF THE AVIAN GROWTH CARTILAGE

被引：77
作者：
HASELGROVE, JC
SHAPIRO, IM
SILVERTON, SF
机构：
[1] UNIV PENN,SCH DENT MED,DEPT ORAL MED,PHILADELPHIA,PA 19104
[2] UNIV PENN,SCH DENT MED,DEPT BIOCHEM,PHILADELPHIA,PA 19104
来源：
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 02期
关键词：
DIFFUSION; KROGH CYLINDER; CHONDROCYTE ENERGY METABOLISM; GROWTH PLATE;
D O I：
10.1152/ajpcell.1993.265.2.C497
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
We have used computer modeling studies to investigate the oxygen supply to the prehypertrophic and hypertrophic regions of avian growth plate. We measured experimentally the characteristics of the oxygen consumption of chondrocytes at different oxygen tensions. The oxygen consumption decreases at low oxygen tensions. This relation between oxygen tension and oxygen consumption serves as a protective mechanism that prevents the cells in the prehypertrophic zone from becoming anoxic in the regions farthest from the blood vessels. The results of the calculations, when combined with redox measurements of the cells in the growth plate, indicate that the metabolism of the chondrocytes is not controlled simply by the available oxygen supply.
引用
收藏
页码：C497 / C506
页数：10
相关论文
共 22 条
  • [1] ALLHANDS RV, 1984, CORNELL VET, V74, P111
  • [2] ARSENAULT AL, 1987, J BONE MINER RES, V2, P143
  • [3] MEMBRANE-TRANSPORT PROPERTIES OF BOVINE ARTICULAR-CARTILAGE[J]. BERNICH, E;RUBENSTEIN, R;BELLIN, JS. BIOCHIMICA ET BIOPHYSICA ACTA, 1976(04)
  • [4] MORPHOLOGICAL OBSERVATIONS CONCERNING THE PATTERN OF MINERALIZATION OF THE NORMAL AND THE RACHITIC CHICK GROWTH CARTILAGE[J]. BOYDE, A;SHAPIRO, IM. ANATOMY AND EMBRYOLOGY, 1987(04)
  • [5] Brighton C T, 1971, Clin Orthop Relat Res, V80, P167, DOI 10.1097/00003086-197110000-00024
  • [6] OXYGEN TENSION IN ZONES OF EPIPHYSEAL PLATE, METAPHYSIS AND DIAPHYSIS - IN-VITRO AND IN-VIVO STUDY IN RATS AND RABBITS[J]. BRIGHTON, CT;HEPPENST.RB. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1971(04)
  • [7] IN VITRO EPIPHYSEAL-PLATE GROWTH IN VARIOUS OXYGEN TENSIONS[J]. BRIGHTON, CT;RAY, RD;SOBLE, LW;KUETTNER, KE. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1969(07)
  • [8] MOVEMENT OF FERRITIN IN THE 2-DAY-OLD CHICK FEMUR[J]. DILLAMAN, RM. ANATOMICAL RECORD, 1984(04)
  • [9] MATHEMATICAL-MODELING OF MICROCIRCULATION[J]. FLETCHER, JE. MATHEMATICAL BIOSCIENCES, 1978(3-4)
  • [10] DIFFUSION OF DISSOLVED GASES IN LIQUIDS[J]. HIMMELBLAU, DM. CHEMICAL REVIEWS, 1964(05)
123