QUANTITATION OF NIZATIDINE IN CAPSULES USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：10

作者：

MATHEW, M ^{[1
]}

DASGUPTA, V ^{[1
]}

BETHEA, C ^{[1
]}

机构：

[1] BEN TAUB GEN HOSP, HOUSTON, TX 77030 USA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 12期

关键词：

D O I：

10.3109/03639049309047187

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stability-indicating high-performance liquid chromatography method for the quantitation of nizatidine in capsules has been developed. The method is accurate and precise with a percent relative standard deviation of 0.34 based on 6 readings. A number of inactive ingredients present in the capsules did not interfere in the assay procedure. The recovery from the synthetic mixtures was quantitative. The extraction procedure from the capsules is very simple. The drug appears to be very sensitive to bases (such as sodium hydroxide) since 100% of the drug decomposed on boiling for 35 minutes. The drug was very stable when boiled with sulfuric acid.

引用

页码：1497 / 1503

页数：7