SYNTHESIS, CHARACTERIZATION, AND ANTICANCER ACTIVITY OF 1,2,3-TRIAZOLE-DERIVED 1,3,4-OXADIAZOLE CONTAINING N-HETEROCYCLIC MOIETIES

被引：0
作者：
Narsimha, Sirassu [1 ]
Lavudya, Sudhakar [1 ]
Hussain, Althaf S. K. [2 ]
Reddy, N. Vasudeva [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, TS, India
[2] Kakatiya Univ, Dept Biotechnol, Warangal 506009, TS, India
来源：
HETEROCYCLIC LETTERS | 2015年 / 5卷 / 04期
关键词：
1,2,3-triazole; Oxadiazole: N-heterocyclic compounds; Anticancer activity;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,4-Disubstituted 1,2,3-triazoles (3a-3j) have been synthesized by one pot [3+2] cycloaddition reaction of 2-(azidomethyl)-5-phenyl-1,3,4-oxadiazole(1) with propargyl bromide and N-heterocyclic compounds (2a-j), respectively. The compounds were evaluated for in vitro anticancer activity against two human cancer cell lines MCF-7 and HeLa. Cisplatin used as a standard drug. Compound 3h has exhibited excellent activity against MCF-7 (IC50 16.93 mu M) than the standard drug Cisplatin. Compound 3j against HeLa (15.97 mu M) have also shown good activity. Remaining compounds have shown moderate to good anticancer activity against both cell lines.
引用
收藏
页码：653 / 660
页数：8
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