SYNTHESIS, CHARACTERIZATION, AND ANTICANCER ACTIVITY OF 1,2,3-TRIAZOLE-DERIVED 1,3,4-OXADIAZOLE CONTAINING N-HETEROCYCLIC MOIETIES

被引：0

作者：

Narsimha, Sirassu ^{[1
]}

Lavudya, Sudhakar ^{[1
]}

Hussain, Althaf S. K. ^{[2
]}

Reddy, N. Vasudeva ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, TS, India

[2] Kakatiya Univ, Dept Biotechnol, Warangal 506009, TS, India

来源：

HETEROCYCLIC LETTERS | 2015年 / 5卷 / 04期

关键词：

1,2,3-triazole; Oxadiazole: N-heterocyclic compounds; Anticancer activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,4-Disubstituted 1,2,3-triazoles (3a-3j) have been synthesized by one pot [3+2] cycloaddition reaction of 2-(azidomethyl)-5-phenyl-1,3,4-oxadiazole(1) with propargyl bromide and N-heterocyclic compounds (2a-j), respectively. The compounds were evaluated for in vitro anticancer activity against two human cancer cell lines MCF-7 and HeLa. Cisplatin used as a standard drug. Compound 3h has exhibited excellent activity against MCF-7 (IC50 16.93 mu M) than the standard drug Cisplatin. Compound 3j against HeLa (15.97 mu M) have also shown good activity. Remaining compounds have shown moderate to good anticancer activity against both cell lines.

引用

页码：653 / 660

页数：8

共 50 条

[1] Evaluation of anticancer activity of some 1,3,4-oxadiazole derivatives
Sengupta, Pinaki
Dash, Deepak Kurnar
Yeligar, Veerendra C.
Murugesh, K.
Rajalingarn, D.
Singh, Jagadish
Maity, T. K.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2008, 47 (03): : 460 - 462
[2] Synthesis of Indole-1,3,4-Oxadiazole Based Sulfonyl 1,2,3-Triazoles as Potent Anticancer and EGFR Inhibitors
Jagan Mohan Reddy Velidandla
Shiva Kumar Koppula
Russian Journal of Bioorganic Chemistry, 2023, 49 : 1337 - 1345
[3] Design, synthesis and anticancer activity of new monastrol analogues bearing 1,3,4-oxadiazole moiety
Ragab, Fatma A. F.
Abou-Seri, Sahar M.
Abdel-Aziz, Salah A.
Alfayomy, Abdallah M.
Aboelmagd, Mohamed
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 : 140 - 151
[4] Synthesis of Indole-1,3,4-Oxadiazole Based Sulfonyl 1,2,3-Triazoles as Potent Anticancer and EGFR Inhibitors
Velidandla, Jagan Mohan Reddy
Koppula, Shiva Kumar
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2023, 49 (06) : 1337 - 1345
[5] Synthesis of Indole-1,3,4-oxadiazole Based Sulfonyl 1,2,4-Oxadiazole Derivatives as EGFR Targeting Anticancer Agents
Dubba, Abhilasha
Koppula, Shiva Kumar
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2023, 93 (11) : 2866 - 2873
[6] Synthesis of Indole-1,3,4-oxadiazole Based Sulfonyl 1,2,4-Oxadiazole Derivatives as EGFR Targeting Anticancer Agents
Abhilasha Dubba
Shiva Kumar Koppula
Russian Journal of General Chemistry, 2023, 93 : 2866 - 2873
[7] Design, synthesis, characterization, molecular docking studies and anticancer activity evaluation of novel hydrazinecarbothioamide, 1,2,4-triazole-3-thione, 4-thiazolidinone and 1,3,4-oxadiazole derivatives
Dincel, Efe Dogukan
Akdag, Cigdem
Kayra, Tulay
Cosar, Ebru Didem
Aksoy, Mehmet Onur
Akalin-Ciftci, Gulsen
Ulusoy-Guzeldemirci, Nuray
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1268
[8] Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,3-triazole incorporated 1,3,4-oxadiazole-Triazine derivatives
Oggu, Sujana
Akshinthala, Parameswari
Katari, Naresh Kumar
Nagarapu, Laxmi Kumari
Malempati, Srimannarayana
Gundla, Rambabu
Jonnalagadda, Sreekantha Babu
HELIYON, 2023, 9 (05)
[9] Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety
Han, Xu
Yu, Yun Long
Ma, Duo
Zhang, Zhao Yan
Liu, Xin Hua
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 344 - 360
[10] Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and Study of Anticancer Activities
Spandana, Zanjam
Sreenivasulu, Reddymasu
MalathiRekha, Tadigiri
Rao, Mandava Venkata Basaveswara
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 16 (06) : 656 - 662

← 1 2 3 4 5 →